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OptiDrop as leap in single-cell analysis

A new study (DOI: 10.1038/s41378-024-00665-w) published on 12 March, 2024, in the journal Microsystems & Nanoengineering, unveiled an innovative technology that enables multiplexed fluorescence and scatter detection with unprecedented single-cell resolution, using on-chip fiber optics within droplet microfluidic applications. The innovative technology behind the OptiDrop platform marks a significant departure from traditional single-cell analysis methods. By incorporating advanced optical fiber technology directly into microfluidic chips, OptiDrop enables on-chip detection of light scatter and fluorescence from droplets. This novel approach allows for precise analysis of cellular components at a level of detail previously considered unachievable, bypassing the need for complex and costly traditional microscopy and high-speed imaging techniques. The platform has been rigorously tested, demonstrating its ability to perform differential expression analysis of cell surface biomarkers, such as major histocompatibility complex proteins. This not only showcases OptiDrop’s potential for detecting subtle biological variations but also highlights its capacity for scalable, high-throughput analysis.

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