First-in-Disease Use of Kyverna Therapeutics‘ KYV-101 in Patients With Progressive Multiple Sc

Two patients were treated with KYV-101, a fully human anti-CD19 CAR T-cell product candidate, in Germany as part of a named patient program after failure to respond to conventional therapies The treatment resulted in an acceptable safety profile, with no observed clinical signs of early neurotoxicity, warranting larger clinical studies in subjects with multiple sclerosis

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https://www.cell.com/med/fulltext/S2666-6340(24)00114-4